Usefulness of adalimumab in the treatment of refractory uveitis associated with juvenile idiopathic arthritis.
Mediators Inflamm
; 2013: 560632, 2013.
Article
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| MEDLINE
| ID: mdl-24489444
ABSTRACT
PURPOSE:
To assess the efficacy and safety of adalimumab in patients with juvenile idiopathic arthritis (JIA) and associated refractory uveitis.DESIGN:
Multicenter, prospective case series.METHODS:
Thirty-nine patients (mean [SD] age of 11.5 [7.9] years) with JIA-associated uveitis who were either not responsive to standard immunosuppressive therapy or intolerant to it were enrolled. Patients aged 13-17 years were treated with 40 mg of adalimumab every other week for 6 months and those aged 4-12 years received 24 mg/m(2) body surface.RESULTS:
Inflammation of the anterior chamber (2.02 [1.16] versus 0.42 [0.62]) and of the posterior segment (2.38 [2.97] versus 0.35 [0.71] decreased significantly between baseline and the final visit (P < 0.001). The mean (SD) macular thickness at baseline was 304.54 (125.03) µ and at the end of follow-up was 230.87 (31.12) µ (P < 0.014). Baseline immunosuppression load was 8.10 (3.99) as compared with 5.08 (3.76) at the final visit (P < 0.001). The mean dose of corticosteroids also decreased from 0.25 (0.43) to 0 (0.02) mg (P < 0.001). No significant side effects requiring discontinuation of therapy were observed.CONCLUSION:
Adalimumab seems to be an effective and safe treatment for JIA-associated refractory uveitis and may reduce steroid requirement.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Artritis Juvenil
/
Uveítis
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Antirreumáticos
/
Anticuerpos Monoclonales Humanizados
Tipo de estudio:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
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Child, preschool
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Female
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Humans
/
Male
Idioma:
En
Revista:
Mediators Inflamm
Asunto de la revista:
BIOQUIMICA
/
PATOLOGIA
Año:
2013
Tipo del documento:
Article
País de afiliación:
España