Protective effect of magnesium preloading on cisplatin-induced nephrotoxicity: a retrospective study.
Jpn J Clin Oncol
; 44(4): 346-54, 2014 Apr.
Article
en En
| MEDLINE
| ID: mdl-24503028
ABSTRACT
OBJECTIVE:
Magnesium supplementation has been reported to have a nephroprotective effect on cisplatin-induced renal dysfunction, but little evidence exists regarding the effect of magnesium preloading before cisplatin administration. We started to include magnesium preloading (8 mEq) in cisplatin-containing treatment regimens in January 2011. The aim of the present study was to evaluate whether magnesium preloading reduces cisplatin-induced nephrotoxicity.METHODS:
We retrospectively reviewed 496 thoracic malignancy patients treated with cisplatin (≥60 mg/m²)-containing regimens as a first-time chemotherapy between January 2009 and December 2011. We compared the incidence of Grade ≥2 serum creatinine elevation according to the Common Terminology Criteria for Adverse Events, version 4.0, between magnesium preloading group (n = 161 [32%]) and non-magnesium preloading group (n = 335 [68%]) during the first cycle and all cycles.RESULTS:
The median number of administered cycles was four in both groups. The incidence of Grade ≥2 serum creatinine elevation in magnesium preloading group was significantly lower during both the first cycle and all cycles than in the non-magnesium preloading group (4.9 versus 19.1% during the first cycle, and 14.2 versus 39.7% during all the cycles). A multivariate analysis indicated that magnesium preloading significantly reduced cisplatin-induced nephrotoxicity throughout the entire period from after the first administration (odds ratio 0.262, 95% confidence interval 0.106-0.596 during the first cycle, and odds ratio 0.234, 95% confidence interval 0.129-0.414 during all cycles).CONCLUSIONS:
Magnesium preloading before cisplatin administration significantly reduced cisplatin-induced nephrotoxicity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cisplatino
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Sustancias Protectoras
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Creatinina
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Lesión Renal Aguda
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Riñón
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Magnesio
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Antineoplásicos
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Jpn J Clin Oncol
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón