Efficacy of azithromycin for treatment of acute exacerbation of chronic fibrosing interstitial pneumonia: a prospective, open-label study with historical controls.
Respiration
; 87(6): 478-84, 2014.
Article
en En
| MEDLINE
| ID: mdl-24802885
ABSTRACT
BACKGROUND:
Acute exacerbation of chronic fibrosing interstitial pneumonia (AE-CFIP) is an often fatal condition with no established treatment. Recently, macrolides were found to be beneficial in cases of acute lung injury.OBJECTIVES:
To examine the clinical effectiveness and safety of intravenous azithromycin in patients hospitalized for AE-CFIP.METHODS:
A prospective, open-label study with historical controls was conducted. Twenty consecutive patients with AE-CFIP received azithromycin. They were compared with a historical cohort treated with fluoroquinolone (n = 56). All patients received high-dose steroid pulse therapy. The primary end point was mortality at 60 days. The secondary end point was safety of intravenous azithromycin in patients with AE-CFIP. Inverse probability of treatment weighting (IPTW) using the propensity score was performed to investigate the relationship between azithromycin use and survival time.RESULTS:
Mortality was significantly lower in the patients treated with azithromycin than in those treated with fluoroquinolone (mortality rate at 60 days 20 vs. 69.6%, p < 0.001; median survival time not reached vs. 29.5 days, p < 0.001). The IPTW adjusted hazard of mortality at 60 days in patients receiving azithromycin was 0.17 (95% CI 0.05-0.61). No serious adverse events were observed.CONCLUSIONS:
Azithromycin was associated with improved outcomes in patients with AE-CFIP. Further studies are needed to verify this finding (Clinical trial JMA-IIA00095).
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Esteroides
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Enfermedades Pulmonares Intersticiales
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Azitromicina
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Fluoroquinolonas
Tipo de estudio:
Clinical_trials
/
Diagnostic_studies
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Observational_studies
/
Risk_factors_studies
Límite:
Aged
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Aged80
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Female
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Humans
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Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Respiration
Año:
2014
Tipo del documento:
Article
País de afiliación:
Japón