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Natural neural projection dynamics underlying social behavior.
Gunaydin, Lisa A; Grosenick, Logan; Finkelstein, Joel C; Kauvar, Isaac V; Fenno, Lief E; Adhikari, Avishek; Lammel, Stephan; Mirzabekov, Julie J; Airan, Raag D; Zalocusky, Kelly A; Tye, Kay M; Anikeeva, Polina; Malenka, Robert C; Deisseroth, Karl.
Afiliación
  • Gunaydin LA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Grosenick L; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Neuroscience Program, Stanford University, Stanford, CA 94305, USA.
  • Finkelstein JC; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Kauvar IV; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Fenno LE; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Neuroscience Program, Stanford University, Stanford, CA 94305, USA.
  • Adhikari A; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Lammel S; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
  • Mirzabekov JJ; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Airan RD; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Zalocusky KA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Neuroscience Program, Stanford University, Stanford, CA 94305, USA.
  • Tye KM; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Anikeeva P; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.
  • Malenka RC; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
  • Deisseroth K; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA. Electronic address: deissero@stanford.edu.
Cell ; 157(7): 1535-51, 2014 Jun 19.
Article en En | MEDLINE | ID: mdl-24949967
ABSTRACT
Social interaction is a complex behavior essential for many species and is impaired in major neuropsychiatric disorders. Pharmacological studies have implicated certain neurotransmitter systems in social behavior, but circuit-level understanding of endogenous neural activity during social interaction is lacking. We therefore developed and applied a new methodology, termed fiber photometry, to optically record natural neural activity in genetically and connectivity-defined projections to elucidate the real-time role of specified pathways in mammalian behavior. Fiber photometry revealed that activity dynamics of a ventral tegmental area (VTA)-to-nucleus accumbens (NAc) projection could encode and predict key features of social, but not novel object, interaction. Consistent with this observation, optogenetic control of cells specifically contributing to this projection was sufficient to modulate social behavior, which was mediated by type 1 dopamine receptor signaling downstream in the NAc. Direct observation of deep projection-specific activity in this way captures a fundamental and previously inaccessible dimension of mammalian circuit dynamics.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Social / Área Tegmental Ventral / Vías Nerviosas / Núcleo Accumbens Límite: Animals Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Conducta Social / Área Tegmental Ventral / Vías Nerviosas / Núcleo Accumbens Límite: Animals Idioma: En Revista: Cell Año: 2014 Tipo del documento: Article País de afiliación: Estados Unidos