[Study on preparation process and formulation optimization of herpetin liposomes].
Zhongguo Zhong Yao Za Zhi
; 39(6): 1007-10, 2014 Mar.
Article
en Zh
| MEDLINE
| ID: mdl-24956840
ABSTRACT
Herpetin (HPT) is an active monomer constituent isolated from lignanoid in seeds of Herpetospermum caudigerum. HPT shows inhibitory effects in hepatic injury and HBV-DNA and the replication. In the study, we successfully prepare herpetin liposomes by film dispersion method for the first time. The prescription process was optimized, with the entrapment efficiency as the index. According to the optimized prescription, the mass ratio of HPT phospholipids cholesterol was 2.4478.05 19.51, the hydration and de-molding process was performed with 0.5% F68 solution at 50 degrees C, and the water-bath ultrasonic time was 20 min. The HPT liposomes prepared by this method showed an average entrapment efficiency of (94.50 +/- 2.15)% and a particle size of (119.2 +/- 10.7) nm, which was consistent with the trial expectations and will lay a solid foundation for the hepatic targeting delivery system in future.
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Banco de datos:
MEDLINE
Asunto principal:
Medicamentos Herbarios Chinos
/
Química Farmacéutica
/
Lignanos
/
Composición de Medicamentos
/
Liposomas
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Asunto de la revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Año:
2014
Tipo del documento:
Article