Biotechnological approach towards a highly efficient production of natural prostaglandins.
Biotechnol Lett
; 36(11): 2193-8, 2014 Nov.
Article
en En
| MEDLINE
| ID: mdl-25048234
ABSTRACT
Prostaglandins (PGs) act as potent local hormones in nearly all tissues of the human body and are used for various medical applications. Heterologous expression of PG endoperoxide H-synthase from the alga, Gracilaria vermiculophylla, into E. coli and the application of this strain in biotransformation experiments resulted in a highly efficient conversion of arachidonic acid (ARA) yielding up to 130 mg natural PGs l(-1) in a laboratory scale approach. Detailed analyses of the products and production kinetics were performed, confirming a rapid conversion of ARA to PGs.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Biotecnología
/
Prostaglandinas
/
Escherichia coli
Idioma:
En
Revista:
Biotechnol Lett
Año:
2014
Tipo del documento:
Article
País de afiliación:
Alemania