Genomic aberrations in myeloid sarcoma without blood or bone marrow involvement: characterization of formalin-fixed paraffin-embedded samples by chromosomal microarrays.
Leuk Res
; 38(9): 1091-6, 2014 Sep.
Article
en En
| MEDLINE
| ID: mdl-25088808
ABSTRACT
Myeloid sarcoma (MS) is a presentation of acute myeloid leukemia (AML) as a tumor mass outside of the bone marrow. Viable cells from MS are frequently unavailable for cytogenetic studies. We therefore investigated whether chromosomal microarray analysis (CMA) using formalin-fixed paraffin-embedded (FFPE) tissues can detect clinically important genetic abnormalities in MS. CMA successfully identified genomic aberrations in six cases of MS, and in two cases it revealed multiple abnormalities equivalent to a complex karyotype, thus predicting a poor outcome. CMA using FFPE material is therefore a feasible and clinically applicable approach for detection of prognostically significant genomic abnormalities in MS.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Aberraciones Cromosómicas
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Adhesión en Parafina
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Análisis Citogenético
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Sarcoma Mieloide
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Análisis por Micromatrices
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Leuk Res
Año:
2014
Tipo del documento:
Article
País de afiliación:
Estados Unidos