Paricalcitol protects against TGF-ß1-induced fibrotic responses in hypoxia and stabilises HIF-&#945; in renal epithelia.

Nolan, Karen A; Brennan, Eoin P; Scholz, Carsten C; Cullen, Cliodhna; Ryan, Aidan; Taylor, Cormac T; Godson, Catherine

Paricalcitol protects against TGF-ß1-induced fibrotic responses in hypoxia and stabilises HIF-α in renal epithelia.

Nolan, Karen A; Brennan, Eoin P; Scholz, Carsten C; Cullen, Cliodhna; Ryan, Aidan; Taylor, Cormac T; Godson, Catherine.

Afiliación

Nolan KA; Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: karenanolan@ucd.ie.
Brennan EP; Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: eoin.brennan@ucd.ie.
Scholz CC; Systems Biology Ireland, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: carsten.scholz@ucd.ie.
Cullen C; Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: cliodhna.cullen@ucdconnect.ie.
Ryan A; Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: jackryan75@gmail.com.
Taylor CT; Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: cormac.taylor@ucd.ie.
Godson C; Diabetes Complications Research Centre, Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: catherine.godson@ucd.ie.

Exp Cell Res ; 330(2): 371-381, 2015 Jan 15.

Article en En | MEDLINE | ID: mdl-25107382

Asunto(s)

Células Epiteliales/efectos de los fármacos; Ergocalciferoles/farmacología; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Riñón/efectos de los fármacos; Riñón/patología; Fosfatidilinositol 3-Quinasas/metabolismo; Factor de Crecimiento Transformador beta1/antagonistas & inhibidores; Actinas/biosíntesis; Factores de Transcripción con Motivo Hélice-Asa-Hélice Básico/metabolismo; Cadherinas/metabolismo; Proteínas de Unión al Calcio/biosíntesis; Hipoxia de la Célula; Línea Celular Transformada; Células Epiteliales/patología; Fibrosis; Humanos; Péptidos y Proteínas de Señalización Intercelular/biosíntesis; Proteína Jagged-1; Proteínas de la Membrana/biosíntesis; Nefritis Intersticial/patología; Fosforilación; Estabilidad Proteica; Interferencia de ARN; Proteínas Serrate-Jagged; Proteína Smad2/metabolismo; Trombospondina 1/biosíntesis; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

Fibrosis; HIF; Hypoxia; Kidney; Paricalcitol; TGF-ß1; Vitamin D

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ergocalciferoles / Fosfatidilinositol 3-Quinasas / Células Epiteliales / Subunidad alfa del Factor 1 Inducible por Hipoxia / Factor de Crecimiento Transformador beta1 / Riñón Límite: Humans Idioma: En Revista: Exp Cell Res Año: 2015 Tipo del documento: Article

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