Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors.

Nair, Vijayalekshmi; Sreevalsan, Sandeep; Basha, Riyaz; Abdelrahim, Maen; Abudayyeh, Ala; Rodrigues Hoffman, Aline; Safe, Stephen

Nair, Vijayalekshmi; Sreevalsan, Sandeep; Basha, Riyaz; Abdelrahim, Maen; Abudayyeh, Ala; Rodrigues Hoffman, Aline; Safe, Stephen.

Afiliación

Nair V; From the Departments of Veterinary Physiology and Pharmacology and.
Sreevalsan S; From the Departments of Veterinary Physiology and Pharmacology and.
Basha R; the Cancer Research Institute, M.D. Anderson Cancer Center-Orlando, Orlando, Florida 32806, the Baylor College of Medicine, Houston, Texas 77030.
Abdelrahim M; the Cancer Research Institute, M.D. Anderson Cancer Center-Orlando, Orlando, Florida 32806, the Baylor College of Medicine, Houston, Texas 77030.
Abudayyeh A; the Department of Emergency Medicine, M.D. Anderson Cancer Center, Houston, Texas 77030, and.
Rodrigues Hoffman A; Veterinary Pathobiology, Texas A&M University, College Station, Texas 77843.
Safe S; From the Departments of Veterinary Physiology and Pharmacology and the Institute of Biosciences and Technology, Texas A&M Health Sciences Center, Houston, Texas 77030 ssafe@cvm.tamu.edu.

J Biol Chem ; 289(40): 27692-701, 2014 Oct 03.

Article en En | MEDLINE | ID: mdl-25143389

Asunto(s)

Antineoplásicos/farmacología; Metformina/farmacología; Neoplasias Pancreáticas/genética; Factores de Transcripción Sp/genética; Serina-Treonina Quinasas TOR/genética; Proteínas ras/genética; Animales; Línea Celular Tumoral; Regulación hacia Abajo/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Masculino; Ratones; Ratones Desnudos; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/metabolismo; Transducción de Señal; Factores de Transcripción Sp/metabolismo; Serina-Treonina Quinasas TOR/antagonistas & inhibidores; Serina-Treonina Quinasas TOR/metabolismo; Proteínas ras/antagonistas & inhibidores; Proteínas ras/metabolismo; Neoplasias Pancreáticas

Palabras clave

Epidermal Growth Factor Receptor (EGFR); Gene Expression; IGFR Down-regulation; Insulin-like Growth Factor (IGF); Metformin; Pancreatic Cancer; Ras Inhibition; Sp Transcription Factors; Specificity Protein 1 (Sp1); mTOR Down-regulation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Proteínas ras / Factores de Transcripción Sp / Serina-Treonina Quinasas TOR / Metformina / Antineoplásicos Límite: Animals / Humans / Male Idioma: En Revista: J Biol Chem Año: 2014 Tipo del documento: Article

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