O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration.
Adv Neurobiol
; 9: 343-66, 2014.
Article
en En
| MEDLINE
| ID: mdl-25151387
ABSTRACT
O-GlcNAc is the attachment of ß-N-acetylglucosamine to the hydroxyl group of serine and threonine in nuclear and cytoplasmic proteins. It is generally not further elongated but exists as a monosaccharide that can be rapidly added or removed. Thousands of proteins involved in gene transcription, protein translation, and degradation as well as the regulation of signal transduction contain O-GlcNAc. Brain is one of the tissues where O-GlcNAc is most highly expressed and deletion of neuronal O-GlcNAc leads to death early in development. O-GlcNAc is also important for normal adult brain function, where dynamic processes like learning and memory at least in part depend on the modification of specific proteins by O-GlcNAc. Conversely, too much or too little O-GlcNAc on other proteins participates in neurodegenerative processes underlying diseases such as Alzheimer's and Parkinson's. In this chapter, we describe the expression and regulation of O-GlcNAc in the nervous system.
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Banco de datos:
MEDLINE
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En
Revista:
Adv Neurobiol
Año:
2014
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Article
País de afiliación:
Estados Unidos