Structural requirements for the collagenase and elastase activity of cathepsin K and its selective inhibition by an exosite inhibitor.

Sharma, Vidhu; Panwar, Preety; O'Donoghue, Anthony J; Cui, Haoran; Guido, Rafael V C; Craik, Charles S; Brömme, Dieter

Sharma, Vidhu; Panwar, Preety; O'Donoghue, Anthony J; Cui, Haoran; Guido, Rafael V C; Craik, Charles S; Brömme, Dieter.

Afiliación

Sharma V; *Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada V6T1Z3.
Panwar P; *Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada V6T1Z3.
O'Donoghue AJ; Department of Pharmaceutical Chemistry, Program in Chemistry and Chemical Biology and Graduate Group in Biophysics, University of California at San Francisco, San Francisco, CA 94143, U.S.A.
Cui H; *Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada V6T1Z3.
Guido RV; Laboratório de Química Medicinal e Computacional, Centro de Inovação em Biodiversidade e Fármacos, Instituto de Física de São Carlos, Universidade de São Paulo, São Carlos-SP 13563-120, Brazil.
Craik CS; Department of Pharmaceutical Chemistry, Program in Chemistry and Chemical Biology and Graduate Group in Biophysics, University of California at San Francisco, San Francisco, CA 94143, U.S.A.
Brömme D; *Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada V6T1Z3.

Biochem J ; 465(1): 163-73, 2015 Jan 01.

Article en En | MEDLINE | ID: mdl-25279554

Asunto(s)

Catepsina K/antagonistas & inhibidores; Catepsina K/química; Colagenasas/metabolismo; Elastasa Pancreática/metabolismo; Inhibidores de Proteasas/farmacología; Secuencia de Aminoácidos; Animales; Dominio Catalítico; Catepsina K/metabolismo; Bovinos; Colágeno/metabolismo; Matriz Extracelular/efectos de los fármacos; Matriz Extracelular/metabolismo; Humanos; Cinética; Modelos Moleculares; Datos de Secuencia Molecular; Proteínas Mutantes/metabolismo; Elastasa Pancreática/antagonistas & inhibidores; Unión Proteica/efectos de los fármacos; Proteolisis/efectos de los fármacos; Relación Estructura-Actividad; Especificidad por Sustrato/efectos de los fármacos

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Inhibidores de Proteasas / Elastasa Pancreática / Colagenasas / Catepsina K Límite: Animals / Humans Idioma: En Revista: Biochem J Año: 2015 Tipo del documento: Article

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