Characterization of clinical and immunological parameters during Ebola virus infection of rhesus macaques.
Viral Immunol
; 28(1): 32-41, 2015 Feb.
Article
en En
| MEDLINE
| ID: mdl-25514385
The rhesus macaque serves as an animal model for Ebola virus (EBOV) infection. A thorough understanding of EBOV infection in this species would aid in further development of filovirus therapeutics and vaccines. In this study, pathological and immunological data from EBOV-infected rhesus macaques are presented. Changes in blood chemistries, hematology, coagulation, and immune parameters during infection, which were consistently observed in the animals, are presented. In an animal that survived challenge, a delay was observed in the detection of viral RNA and inflammatory cytokines and chemokines which may have contributed to survival. Collectively, these data add to the body of knowledge regarding EBOV pathogenesis in rhesus macaques and emphasize the reproducibility of the rhesus macaque challenge model.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades de los Primates
/
Fiebre Hemorrágica Ebola
/
Ebolavirus
Límite:
Animals
Idioma:
En
Revista:
Viral Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
VIROLOGIA
Año:
2015
Tipo del documento:
Article