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High-speed label-free functional photoacoustic microscopy of mouse brain in action.
Yao, Junjie; Wang, Lidai; Yang, Joon-Mo; Maslov, Konstantin I; Wong, Terence T W; Li, Lei; Huang, Chih-Hsien; Zou, Jun; Wang, Lihong V.
Afiliación
  • Yao J; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Wang L; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Yang JM; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Maslov KI; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Wong TT; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Li L; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
  • Huang CH; Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas, USA.
  • Zou J; Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas, USA.
  • Wang LV; Optical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri, USA.
Nat Methods ; 12(5): 407-10, 2015 May.
Article en En | MEDLINE | ID: mdl-25822799
ABSTRACT
We present fast functional photoacoustic microscopy (PAM) for three-dimensional high-resolution, high-speed imaging of the mouse brain, complementary to other imaging modalities. We implemented a single-wavelength pulse-width-based method with a one-dimensional imaging rate of 100 kHz to image blood oxygenation with capillary-level resolution. We applied PAM to image the vascular morphology, blood oxygenation, blood flow and oxygen metabolism in both resting and stimulated states in the mouse brain.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Técnicas Fotoacústicas / Microscopía Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Técnicas Fotoacústicas / Microscopía Límite: Animals Idioma: En Revista: Nat Methods Asunto de la revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos