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Assessing the oral bioavailability of difluorosialic acid prodrugs, potent viral neuraminidase inhibitors, using a snapshot PK screening assay.
Arns, Steve; Tan, Jason; Sun, Sharon; Galey, Adam; Zisman, Natalia; Ross, Fiona; Udechukwu, Jenna; Dercho, Samantha; Gusti, Vionarica; Paquette, Jay; Webb, Murray; Bourque, Elyse; Withers, Stephen G; Liggins, Richard.
Afiliación
  • Arns S; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada. Electronic address: sarns@cdrd.ca.
  • Tan J; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Sun S; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Galey A; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Zisman N; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Ross F; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Udechukwu J; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Dercho S; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Gusti V; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Paquette J; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Webb M; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Bourque E; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
  • Withers SG; Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.
  • Liggins R; The Center for Drug Research and Development, 4th Floor-2405 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
Bioorg Med Chem Lett ; 25(12): 2505-9, 2015 Jun 15.
Article en En | MEDLINE | ID: mdl-25980910
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Siálicos / Proteínas Virales / Profármacos / Inhibidores Enzimáticos / Neuraminidasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ácidos Siálicos / Proteínas Virales / Profármacos / Inhibidores Enzimáticos / Neuraminidasa Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2015 Tipo del documento: Article