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Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo.
Spiess, Katja; Jeppesen, Mads G; Malmgaard-Clausen, Mikkel; Krzywkowski, Karen; Dulal, Kalpana; Cheng, Tong; Hjortø, Gertrud M; Larsen, Olav; Burg, John S; Jarvis, Michael A; Garcia, K Christopher; Zhu, Hua; Kledal, Thomas N; Rosenkilde, Mette M.
Afiliación
  • Spiess K; INAGEN ApS., DK-2800 Kongens Lyngby, Denmark; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Jeppesen MG; INAGEN ApS., DK-2800 Kongens Lyngby, Denmark;
  • Malmgaard-Clausen M; INAGEN ApS., DK-2800 Kongens Lyngby, Denmark;
  • Krzywkowski K; INAGEN ApS., DK-2800 Kongens Lyngby, Denmark;
  • Dulal K; Department of Microbiology and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ 07184;
  • Cheng T; National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, Xiamen University, 361100 Fujian Province, China;
  • Hjortø GM; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Larsen O; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark;
  • Burg JS; Stanford University School of Medicine, Stanford, CA 94305; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305;
  • Jarvis MA; School of Biomedical and Healthcare Sciences, University of Plymouth, Plymouth PL4 8AA, United Kingdom.
  • Garcia KC; Stanford University School of Medicine, Stanford, CA 94305; Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305; kcgarcia@stanford.edu tnkl@vet.dtu.dk rosenkilde@sund.ku.dk.
  • Zhu H; Department of Microbiology and Molecular Genetics, Rutgers-New Jersey Medical School, Newark, NJ 07184;
  • Kledal TN; INAGEN ApS., DK-2800 Kongens Lyngby, Denmark; kcgarcia@stanford.edu tnkl@vet.dtu.dk rosenkilde@sund.ku.dk.
  • Rosenkilde MM; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; kcgarcia@stanford.edu tnkl@vet.dtu.dk rosenkilde@sund.ku.dk.
Proc Natl Acad Sci U S A ; 112(27): 8427-32, 2015 Jul 07.
Article en En | MEDLINE | ID: mdl-26080445
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Proteínas Virales / Proteínas Recombinantes de Fusión / Infecciones por Citomegalovirus / Receptores de Quimiocina / Quimiocina CX3CL1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Proteínas Virales / Proteínas Recombinantes de Fusión / Infecciones por Citomegalovirus / Receptores de Quimiocina / Quimiocina CX3CL1 Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article