Mycobacterial glycolipids di-O-acylated trehalose and tri-O-acylated trehalose downregulate inducible nitric oxide synthase and nitric oxide production in macrophages.
BMC Immunol
; 16: 38, 2015 Jun 23.
Article
en En
| MEDLINE
| ID: mdl-26100760
ABSTRACT
BACKGROUND:
Tuberculosis (TB) remains a serious human health problem that affects millions of people in the world. Understanding the biology of Mycobacterium tuberculosis (Mtb) is essential for tackling this devastating disease. Mtb possesses a very complex cell envelope containing a variety of lipid components that participate in the establishment of the infection. We have previously demonstrated that di-O-acylated trehalose (DAT), a non-covalently linked cell wall glycolipid, inhibits the proliferation of T lymphocytes and the production of cytokines.RESULTS:
In this work we show that DAT and the closely related tri-O-acylated trehalose (TAT) inhibits nitric oxide (NO) production and the inducible nitric oxide synthase (iNOS) expression in macrophages (MØ).CONCLUSIONS:
These findings show that DAT and TAT are cell-wall located virulence factors that downregulate an important effector of the immune response against mycobacteria.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trehalosa
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Glucolípidos
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Óxido Nítrico Sintasa de Tipo II
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Macrófagos
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Mycobacterium
/
Óxido Nítrico
Límite:
Animals
Idioma:
En
Revista:
BMC Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
México