Alpinetin inhibits lipopolysaccharide-induced acute kidney injury in mice.
Int Immunopharmacol
; 28(2): 1003-8, 2015 Oct.
Article
en En
| MEDLINE
| ID: mdl-26321118
ABSTRACT
Alpinetin, a novel plant flavonoid isolated from Alpinia katsumadai Hayata, has been demonstrated to have anti-inflammatory and antioxidant effects. However, the effects of alpinetin on lipopolysaccharide (LPS)-induced acute kidney injury have not been reported. In the present study, we investigated the protective effects and the underlying mechanism of alpinetin against LPS-induced acute kidney injury in mice. The results showed that alpinetin inhibited LPS-induced kidney histopathologic changes, blood urea nitrogen (BUN) and creatinine levels. Alpinetin also inhibited LPS-induced ROS, MDA, and inflammatory cytokines TNF-α, IL-6 and IL-1ß production in kidney tissues. Meanwhile, Western blot analysis showed that alpinetin suppressed LPS-induced TLR4 expression and NF-κB activation in kidney tissues. In addition, alpinetin was found to up-regulate the expression of Nrf2 and HO-1 in a dose-dependent manner. In conclusion, alpinetin protected LPS-induced kidney injury through activating Nrf2 and inhibiting TLR4 expression.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Alpinia
/
Flavanonas
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Lesión Renal Aguda
/
Riñón
/
Antiinflamatorios
/
Antioxidantes
Límite:
Animals
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Humans
/
Male
Idioma:
En
Revista:
Int Immunopharmacol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
Año:
2015
Tipo del documento:
Article
País de afiliación:
China