Increased HCN channel driven inward rectification in benign cramp fasciculation syndrome.
Brain
; 138(Pt 11): 3168-79, 2015 Nov.
Article
en En
| MEDLINE
| ID: mdl-26342125
ABSTRACT
Muscle cramps are a common complaint associated with sudden painful involuntary contractions of a muscle. The mechanisms responsible for muscle cramps are still not clear. Axonal excitability and multi-unit electromyography studies were performed in 20 patients suffering from benign cramp fasciculation syndrome, not currently on medication. The measures of axonal excitability suggested greater inward rectification, indicative of an increase in Ih. Mathematical modelling suggested that the data were best explained by depolarization of the voltage dependence of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Parameters associated with polarization of resting membrane potential were not changed. These findings suggest that a role for HCN channels may become apparent during the rhythmic discharge associated with a voluntary contraction. Consistent with this view, patients had higher motor unit discharge rates than healthy controls during maximal voluntary effort.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Axones
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Canales Regulados por Nucleótidos Cíclicos Activados por Hiperpolarización
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Potenciales de la Membrana
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Neuronas Motoras
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Contracción Muscular
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Calambre Muscular
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Enfermedades Neuromusculares
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Brain
Año:
2015
Tipo del documento:
Article
País de afiliación:
Alemania