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Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.
Matson, David J; Hamamoto, Darryl T; Bregman, Howard; Cooke, Melanie; DiMauro, Erin F; Huang, Liyue; Johnson, Danielle; Li, Xingwen; McDermott, Jeff; Morgan, Carrie; Wilenkin, Ben; Malmberg, Annika B; McDonough, Stefan I; Simone, Donald A.
Afiliación
  • Matson DJ; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Hamamoto DT; Department of Diagnostics and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America.
  • Bregman H; Department of Medicinal Chemistry, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Cooke M; Department of Pharmaceutics Research & Development, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • DiMauro EF; Department of Medicinal Chemistry, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Huang L; Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Johnson D; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Li X; Department of Pharmacokinetics & Drug Metabolism, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • McDermott J; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Morgan C; Department of Pharmaceutics Research & Development, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Wilenkin B; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Malmberg AB; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • McDonough SI; Department of Neuroscience, Amgen Inc., Cambridge, Massachusetts, United States of America.
  • Simone DA; Department of Diagnostics and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, United States of America.
PLoS One ; 10(9): e0138140, 2015.
Article en En | MEDLINE | ID: mdl-26379236
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dolor / Tetrodotoxina / Nociceptores / Fibras Nerviosas Amielínicas / Canal de Sodio Activado por Voltaje NAV1.7 / Analgésicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dolor / Tetrodotoxina / Nociceptores / Fibras Nerviosas Amielínicas / Canal de Sodio Activado por Voltaje NAV1.7 / Analgésicos Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos