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Anticancer Platelet-Mimicking Nanovehicles.
Hu, Quanyin; Sun, Wujin; Qian, Chengen; Wang, Chao; Bomba, Hunter N; Gu, Zhen.
Afiliación
  • Hu Q; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
  • Sun W; Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Qian C; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
  • Wang C; Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
  • Bomba HN; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695, USA.
  • Gu Z; Division of Molecular Pharmaceutics and Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Adv Mater ; 27(44): 7043-50, 2015 Nov 25.
Article en En | MEDLINE | ID: mdl-26416431
ABSTRACT
A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. This PM-coated nanovehicle can also effectively eliminate the circulating tumor cells in vivo and inhibit development of tumor metastasis.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plaquetas / Portadores de Fármacos / Materiales Biomiméticos / Nanoestructuras / Nanomedicina / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plaquetas / Portadores de Fármacos / Materiales Biomiméticos / Nanoestructuras / Nanomedicina / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos