Your browser doesn't support javascript.
loading
Disruption of histone methylation in developing sperm impairs offspring health transgenerationally.
Siklenka, Keith; Erkek, Serap; Godmann, Maren; Lambrot, Romain; McGraw, Serge; Lafleur, Christine; Cohen, Tamara; Xia, Jianguo; Suderman, Matthew; Hallett, Michael; Trasler, Jacquetta; Peters, Antoine H F M; Kimmins, Sarah.
Afiliación
  • Siklenka K; Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
  • Erkek S; Friedrich Miescher Institute for Biomedical Research (FMI), CH-4058 Basel, Switzerland. Faculty of Sciences, University of Basel, Basel, Switzerland.
  • Godmann M; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.
  • Lambrot R; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.
  • McGraw S; Department of Pediatrics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
  • Lafleur C; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.
  • Cohen T; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.
  • Xia J; Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada. Institute of Parasitology, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada.
  • Suderman M; MRC Integrative Epidemiology Unity, School of Social and Community Medicine, University of Bristol, Bristol, UK.
  • Hallett M; McGill Centre for Bioinformatics, School of Computer Science, Faculty of Science, McGill University, Montreal, Quebec, Canada.
  • Trasler J; Department of Pediatrics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Department of Human Genetics and Department of Pharmacology and Therapeutics, Research Institute of the McGill University Health Centre at the Montreal Children's Hospital, Montreal, Quebec, Canada.
  • Peters AH; Friedrich Miescher Institute for Biomedical Research (FMI), CH-4058 Basel, Switzerland. Faculty of Sciences, University of Basel, Basel, Switzerland. sarah.kimmins@mcgill.ca antoine.peters@fmi.ch.
  • Kimmins S; Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada. Department of Animal Science, Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, Quebec, Canada. sarah.kimmins@mcgill.ca antoine.peters@fmi.ch.
Science ; 350(6261): aab2006, 2015 Nov 06.
Article en En | MEDLINE | ID: mdl-26449473
ABSTRACT
A father's lifetime experiences can be transmitted to his offspring to affect health and development. However, the mechanisms underlying paternal epigenetic transmission are unclear. Unlike in somatic cells, there are few nucleosomes in sperm, and their function in epigenetic inheritance is unknown. We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm. KDM1A overexpression in one generation severely impaired development and survivability of offspring. These defects persisted transgenerationally in the absence of KDM1A germline expression and were associated with altered RNA profiles in sperm and offspring. We show that epigenetic inheritance of aberrant development can be initiated by histone demethylase activity in developing sperm, without changes to DNA methylation at CpG-rich regions.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Espermatogénesis / Espermatozoides / Anomalías Congénitas / Histonas / Regulación del Desarrollo de la Expresión Génica / Epigénesis Genética / Histona Demetilasas Límite: Animals Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Canadá

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Espermatogénesis / Espermatozoides / Anomalías Congénitas / Histonas / Regulación del Desarrollo de la Expresión Génica / Epigénesis Genética / Histona Demetilasas Límite: Animals Idioma: En Revista: Science Año: 2015 Tipo del documento: Article País de afiliación: Canadá