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Synthesis of the biotinylated anti-HIV compound BMMP and the target identification study.
Kamo, Masahiro; Tateishi, Hiroshi; Koga, Ryoko; Okamoto, Yoshinari; Otsuka, Masami; Fujita, Mikako.
Afiliación
  • Kamo M; Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: 141y1023@st.kumamoto-u.ac.jp.
  • Tateishi H; Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: 155y2008@st.kumamoto-u.ac.jp.
  • Koga R; Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: kk1205@kumamoto-u.ac.jp.
  • Okamoto Y; Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: okamoto@gpo.kumamoto-u.ac.jp.
  • Otsuka M; Department of Bioorganic Medicinal Chemistry, Faculty of Life Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: motsuka@gpo.kumamoto-u.ac.jp.
  • Fujita M; Research Institute for Drug Discovery, School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan. Electronic address: mfujita@kumamoto-u.ac.jp.
Bioorg Med Chem Lett ; 26(1): 43-5, 2016 Jan 01.
Article en En | MEDLINE | ID: mdl-26615887
BMMP [2-(benzothiazol-2-ylmethylthio)-4-methylpyrimidine], an inhibitor of HIV-1 replication, was linked to biotin to study the interaction with the presumed target, HIV-1 Pr55(Gag) or CA, by means of surface plasmon resonance. The synthesized Biotin-BMMP inhibited HIV-1 replication to a similar extent as BMMP alone, but did not interact with Pr55(Gag) or CA, suggesting that BMMP exerts its activity by a different mechanism.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / VIH-1 / Fármacos Anti-VIH / Biotinilación / Benzotiazoles Tipo de estudio: Diagnostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / VIH-1 / Fármacos Anti-VIH / Biotinilación / Benzotiazoles Tipo de estudio: Diagnostic_studies Idioma: En Revista: Bioorg Med Chem Lett Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2016 Tipo del documento: Article