Determination of residual levels of naloxone, yohimbine, thiophanate, and altrenogest in porcine muscle using QuEChERS with liquid chromatography and triple quadrupole mass spectrometry.
J Sep Sci
; 39(5): 835-41, 2016 Mar.
Article
en En
| MEDLINE
| ID: mdl-26697949
ABSTRACT
A quick, easy, cheap, effective, rugged, and safe QuEChERS (method) was used for the simultaneous detection of four veterinary drug residues, namely naloxone, yohimbine, thiophanate, and altrenogest, in porcine muscle, using liquid chromatography with electrospray ionization triple quadrupole tandem mass spectrometry. Because of the unavailability of a suitable internal standard, matrix-matched calibrations were used for quantification, with determination coefficients ≥ 0.9542. The accuracy (expressed as recovery %) ranged from 60.53 to 83.25%, and the intra- and interday precisions (expressed as relative standard deviations) were <12%. The limits of quantification were 5, 0.5, 2, and 5 ng/g for naloxone, yohimbine, thiophanate, and altrenogest, respectively. Samples purchased from local markets in Seoul, Republic of Korea, revealed no traces of the target analytes. The developed method described herein is sensitive and reliable and can be applied to quantify the tested veterinary drugs in animal tissues.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tiofanato
/
Acetato de Trembolona
/
Yohimbina
/
Residuos de Medicamentos
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Drogas Veterinarias
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Extracción en Fase Sólida
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Músculos
/
Naloxona
Tipo de estudio:
Evaluation_studies
Límite:
Animals
Idioma:
En
Revista:
J Sep Sci
Año:
2016
Tipo del documento:
Article