PP2A as a master regulator of the cell cycle.
Crit Rev Biochem Mol Biol
; 51(3): 162-84, 2016.
Article
en En
| MEDLINE
| ID: mdl-26906453
ABSTRACT
Protein phosphatase 2A (PP2A) plays a critical multi-faceted role in the regulation of the cell cycle. It is known to dephosphorylate over 300 substrates involved in the cell cycle, regulating almost all major pathways and cell cycle checkpoints. PP2A is involved in such diverse processes by the formation of structurally distinct families of holoenzymes, which are regulated spatially and temporally by specific regulators. Here, we review the involvement of PP2A in the regulation of three cell signaling pathways wnt, mTOR and MAP kinase, as well as the G1âS transition, DNA synthesis and mitotic initiation. These processes are all crucial for proper cell survival and proliferation and are often deregulated in cancer and other diseases.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ciclo Celular
/
Proteína Fosfatasa 2
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Crit Rev Biochem Mol Biol
Asunto de la revista:
BIOLOGIA MOLECULAR
/
BIOQUIMICA
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos