Condensin-Based Chromosome Organization from Bacteria to Vertebrates.
Cell
; 164(5): 847-57, 2016 Feb 25.
Article
en En
| MEDLINE
| ID: mdl-26919425
ABSTRACT
Condensins are large protein complexes that play a central role in chromosome organization and segregation in the three domains of life. They display highly characteristic, rod-shaped structures with SMC (structural maintenance of chromosomes) ATPases as their core subunits and organize large-scale chromosome structure through active mechanisms. Most eukaryotic species have two distinct condensin complexes whose balanced usage is adapted flexibly to different organisms and cell types. Studies of bacterial condensins provide deep insights into the fundamental mechanisms of chromosome segregation. This Review surveys both conserved features and rich variations of condensin-based chromosome organization and discusses their evolutionary implications.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cromosomas
/
Adenosina Trifosfatasas
/
Complejos Multiproteicos
/
Proteínas de Unión al ADN
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2016
Tipo del documento:
Article