Gammaherpesvirus targets peritoneal B-1 B cells for long-term latency.
Virology
; 492: 140-4, 2016 May.
Article
en En
| MEDLINE
| ID: mdl-26945150
ABSTRACT
Gammaherpesviruses establish life-long infection in most adults and are associated with the development of B cell lymphomas. While the interaction between gammaherpesviruses and splenic B cells has been explored, very little is known about gammaherpesvirus infection of B-1 B cells, innate-like B cells that primarily reside in body cavities. This study demonstrates that B-1 B cells harbor the highest frequency of latently infected cells in the peritoneum throughout chronic infection, highlighting a previously unappreciated feature of gammaherpesvirus biology.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bazo
/
Subgrupos de Linfocitos B
/
Gammaherpesvirinae
/
Infecciones por Herpesviridae
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Células Mieloides
/
Interacciones Huésped-Patógeno
Límite:
Animals
Idioma:
En
Revista:
Virology
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos