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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool.
Sannerud, Ragna; Esselens, Cary; Ejsmont, Paulina; Mattera, Rafael; Rochin, Leila; Tharkeshwar, Arun Kumar; De Baets, Greet; De Wever, Veerle; Habets, Roger; Baert, Veerle; Vermeire, Wendy; Michiels, Christine; Groot, Arjan J; Wouters, Rosanne; Dillen, Katleen; Vints, Katlijn; Baatsen, Pieter; Munck, Sebastian; Derua, Rita; Waelkens, Etienne; Basi, Guriqbal S; Mercken, Mark; Vooijs, Marc; Bollen, Mathieu; Schymkowitz, Joost; Rousseau, Frederic; Bonifacino, Juan S; Van Niel, Guillaume; De Strooper, Bart; Annaert, Wim.
Afiliación
  • Sannerud R; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Esselens C; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Ejsmont P; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Mattera R; Cell Biology and Neurobiology Branch, NICHD, NIH, Bethesda, MD 20892, USA.
  • Rochin L; Institut Curie, PSL Research University, CNRS, UMR 144, Paris 75005, France; CNRS, UMR 144, Paris 75005, France.
  • Tharkeshwar AK; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • De Baets G; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • De Wever V; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Habets R; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands.
  • Baert V; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Vermeire W; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Michiels C; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Groot AJ; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands.
  • Wouters R; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Dillen K; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
  • Vints K; VIB BioImaging Core, 3000 Leuven, Belgium.
  • Baatsen P; VIB BioImaging Core, 3000 Leuven, Belgium.
  • Munck S; VIB BioImaging Core, 3000 Leuven, Belgium.
  • Derua R; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Waelkens E; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Basi GS; Avalanche Biotechnology, Menlo Park, CA 94025, USA.
  • Mercken M; Janssen Pharmaceutica, 2340 Beerse, Belgium.
  • Vooijs M; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands.
  • Bollen M; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Schymkowitz J; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Rousseau F; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium.
  • Bonifacino JS; Cell Biology and Neurobiology Branch, NICHD, NIH, Bethesda, MD 20892, USA.
  • Van Niel G; Institut Curie, PSL Research University, CNRS, UMR 144, Paris 75005, France; CNRS, UMR 144, Paris 75005, France.
  • De Strooper B; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1E 6BT, UK.
  • Annaert W; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. Electronic address: wim.annaert@cme.vib-kuleuven.be.
Cell ; 166(1): 193-208, 2016 Jun 30.
Article en En | MEDLINE | ID: mdl-27293189
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Secretasas de la Proteína Precursora del Amiloide / Presenilina-2 / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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XML
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Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Péptidos beta-Amiloides / Secretasas de la Proteína Precursora del Amiloide / Presenilina-2 / Enfermedad de Alzheimer Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Cell Año: 2016 Tipo del documento: Article País de afiliación: Bélgica