Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition.
Biochem Soc Trans
; 44(4): 1117-34, 2016 08 15.
Article
en En
| MEDLINE
| ID: mdl-27528760
ABSTRACT
Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-ß (TGF-ß) family signalling pathway. Similar to TGF-ß, the complex roles of BMPs in development and disease are demonstrated by their dichotomous roles in various cancers and cancer stages. Although early studies implicated BMP signalling in tumour suppressive phenotypes, the results of more recent experiments recognize BMPs as potent tumour promoters. Many of these complexities are becoming illuminated by understanding the role of BMPs in their contextual role in unique cell types of cancer and the impact of their surrounding tumour microenvironment. Here we review the emerging roles of BMP signalling in cancer, with a focus on the molecular underpinnings of BMP signalling in individual cancers as a valid therapeutic target for cancer prevention and treatment.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas Morfogenéticas Óseas
/
Microambiente Tumoral
/
Neoplasias
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Biochem Soc Trans
Año:
2016
Tipo del documento:
Article
País de afiliación:
Estados Unidos