The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT1A, D2 and TAAR1 receptors.

De Gregorio, Danilo; Posa, Luca; Ochoa-Sanchez, Rafael; McLaughlin, Ryan; Maione, Sabatino; Comai, Stefano; Gobbi, Gabriella

The hallucinogen d-lysergic diethylamide (LSD) decreases dopamine firing activity through 5-HT_1A, D₂ and TAAR₁ receptors.

De Gregorio, Danilo; Posa, Luca; Ochoa-Sanchez, Rafael; McLaughlin, Ryan; Maione, Sabatino; Comai, Stefano; Gobbi, Gabriella.

Afiliación

De Gregorio D; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada; Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, Naples, Italy.
Posa L; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada.
Ochoa-Sanchez R; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada.
McLaughlin R; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada.
Maione S; Department of Experimental Medicine, Division of Pharmacology, Second University of Naples, Naples, Italy.
Comai S; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada.
Gobbi G; Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, QC, Canada. Electronic address: gabriella.gobbi@mcgill.ca.

Pharmacol Res ; 113(Pt A): 81-91, 2016 11.

Article en En | MEDLINE | ID: mdl-27544651

Asunto(s)

Dopamina/metabolismo; Alucinógenos/farmacología; Dietilamida del Ácido Lisérgico/farmacología; Receptor de Serotonina 5-HT1A/metabolismo; Receptores de Dopamina D2/metabolismo; Receptores Acoplados a Proteínas G/metabolismo; Animales; Benzamidas/farmacología; Masculino; Neuronas/efectos de los fármacos; Piperazinas/farmacología; Piridinas/farmacología; Pirrolidinas/farmacología; Ratas; Ratas Sprague-Dawley; Serotonina/metabolismo; Área Tegmental Ventral/efectos de los fármacos; Área Tegmental Ventral/metabolismo

Palabras clave

8-OH-DPAT (PubChem CID:1220); Apomorphine (PubChem CID: 6005); Dopamine; EPPTB (PubChem CID: 25175634); Haloperidol (PubChem CID: 3559); In-vivo electrophysiology; LSD; LSD (PubChem CID: 5761); MDL 100,907 (PubChem CID:60858); Serotonin; TAAR(1) receptor; WAY 100,635 (PubChem CID: 5684); p-chlorophenylalanine (PubChem CID: 39972)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Dopamina / Receptores de Dopamina D2 / Receptores Acoplados a Proteínas G / Receptor de Serotonina 5-HT1A / Alucinógenos / Dietilamida del Ácido Lisérgico Límite: Animals Idioma: En Revista: Pharmacol Res Asunto de la revista: FARMACOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia

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