Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-&#954;B-mediated inflammation.

Hua, Fu-Zhou; Ying, Jun; Zhang, Jing; Wang, Xi-Feng; Hu, Yan-Hui; Liang, Ying-Ping; Liu, Qin; Xu, Guo-Hai

Naringenin pre-treatment inhibits neuroapoptosis and ameliorates cognitive impairment in rats exposed to isoflurane anesthesia by regulating the PI3/Akt/PTEN signalling pathway and suppressing NF-κB-mediated inflammation.

Hua, Fu-Zhou; Ying, Jun; Zhang, Jing; Wang, Xi-Feng; Hu, Yan-Hui; Liang, Ying-Ping; Liu, Qin; Xu, Guo-Hai.

Afiliación

Hua FZ; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Ying J; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Zhang J; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Wang XF; Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330039, P.R. China.
Hu YH; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Liang YP; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Liu Q; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
Xu GH; Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Int J Mol Med ; 38(4): 1271-80, 2016 Oct.

Article en En | MEDLINE | ID: mdl-27572468

Asunto(s)

Anestesia; Apoptosis/efectos de los fármacos; Disfunción Cognitiva/tratamiento farmacológico; Flavanonas/uso terapéutico; Inflamación/patología; FN-kappa B/metabolismo; Neuronas/patología; Transducción de Señal; Administración por Inhalación; Animales; Conducta Animal/efectos de los fármacos; Caspasa 3/metabolismo; Disfunción Cognitiva/patología; Disfunción Cognitiva/fisiopatología; Femenino; Flavanonas/farmacología; Inflamación/metabolismo; Isoflurano; Aprendizaje por Laberinto/efectos de los fármacos; Memoria/efectos de los fármacos; Neuronas/efectos de los fármacos; Fosfohidrolasa PTEN/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Ratas Sprague-Dawley; Transducción de Señal/efectos de los fármacos

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B / Apoptosis / Flavanonas / Disfunción Cognitiva / Inflamación / Anestesia / Neuronas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Int J Mol Med Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2016 Tipo del documento: Article

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