Low-Dose Aspirin and Sporadic Anovulation in the EAGeR Randomized Trial.
J Clin Endocrinol Metab
; 102(1): 86-92, 2017 01 01.
Article
en En
| MEDLINE
| ID: mdl-27754808
ABSTRACT
Context Among women with a single, recent pregnancy loss, daily preconception low-dose aspirin (LDA) increased the live birth rate with no effect on pregnancy loss. Ovulation is a potential mechanism underlying this effect. Objective:
We estimated the effect of LDA on the per-cycle risk of anovulation among eumenorrheic women.Design:
Multicenter, randomized, double-blind, placebo-controlled trial of daily LDA on reproductive outcomes. Preconception follow-up lasted 1 to 6 menstrual cycles (ClinicalTrials.gov, NCT00467363).Setting:
Four US medical centers during 2007 to 2011. Patients or OtherParticipants:
Healthy women (n = 1214), age 18 to 40, were attempting pregnancy, had regular menstrual cycles (21 to 42 days), and had a history of 1 to 2 documented pregnancy losses, ≤2 live births, and no infertility. All participants completed at least 1 menstrual cycle of follow-up; none withdrew due to adverse events. Intervention Aspirin (81 mg) daily for 1 to 6 menstrual cycles. Main OutcomeMeasure:
Per-cycle risk of anovulation, defined as the absence of both a positive spot-urine pregnancy test and a luteinizing hormone (LH) peak (2.5-fold increase in daily urinary LH). Hypothesis formulation preceded data collection.Results:
Among 4340 cycles, LDA was not associated with anovulation (LDA 13.4%, placebo 11.1%; risk ratio = 1.16, 95% confidence interval, 0.88 to 1.52). Results were similar among women with a single, recent loss.Conclusions:
Daily LDA had no effect on anovulation among women with a history of 1 to 2 pregnancy losses. LDA may affect fertility via other pathways, and these warrant further study.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inhibidores de Agregación Plaquetaria
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Aspirina
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Anovulación
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
J Clin Endocrinol Metab
Año:
2017
Tipo del documento:
Article