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The Effect of Cage Shape on Nanoparticle-Based Drug Carriers: Anticancer Drug Release and Efficacy via Receptor Blockade Using Dextran-Coated Iron Oxide Nanocages.
Rampersaud, Sham; Fang, Justin; Wei, Zengyan; Fabijanic, Kristina; Silver, Stefan; Jaikaran, Trisha; Ruiz, Yuleisy; Houssou, Murielle; Yin, Zhiwei; Zheng, Shengping; Hashimoto, Ayako; Hoshino, Ayuko; Lyden, David; Mahajan, Shahana; Matsui, Hiroshi.
Afiliación
  • Rampersaud S; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Fang J; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Wei Z; Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
  • Fabijanic K; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Silver S; Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
  • Jaikaran T; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Ruiz Y; Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
  • Houssou M; Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
  • Yin Z; Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
  • Zheng S; Department of Medical Laboratory Sciences, Hunter College, City University of New York , 425 East 25th Street, New York, New York 10010, United States.
  • Hashimoto A; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Hoshino A; Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
  • Lyden D; Department of Chemistry, Hunter College, City University of New York , 695 Park Avenue, New York, New York 10065, United States.
  • Mahajan S; Department of Chemistry, The Graduate Center of City University of New York , 365 Fifth Avenue, New York, New York 10016, United States.
  • Matsui H; Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine , New York, New York 10021, United States.
Nano Lett ; 16(12): 7357-7363, 2016 12 14.
Article en En | MEDLINE | ID: mdl-27960523
Although a range of nanoparticles have been developed as drug delivery systems in cancer therapeutics, this approach faces several important challenges concerning nanocarrier circulation, clearance, and penetration. The impact of reducing nanoparticle size on penetration through leaky blood vessels around tumor microenvironments via enhanced permeability and retention (EPR) effect has been extensively examined. Recent research has also investigated the effect of nanoparticle shape on circulation and target binding affinity. However, how nanoparticle shape affects drug release and therapeutic efficacy has not been previously explored. Here, we compared the drug release and efficacy of iron oxide nanoparticles possessing either a cage shape (IO-NCage) or a solid spherical shape (IO-NSP). Riluzole cytotoxicity against metastatic cancer cells was enhanced 3-fold with IO-NCage. The shape of nanoparticles (or nanocages) affected the drug release point and cellular internalization, which in turn influenced drug efficacy. Our study provides evidence that the shape of iron oxide nanoparticles has a significant impact on drug release and efficacy.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Portadores de Fármacos / Compuestos Férricos / Dextranos / Nanopartículas Límite: Humans Idioma: En Revista: Nano Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Portadores de Fármacos / Compuestos Férricos / Dextranos / Nanopartículas Límite: Humans Idioma: En Revista: Nano Lett Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos