Attenuation of Phosphorylation-dependent Activation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Disease-causing Mutations at the Transmission Interface.

Chin, Stephanie; Yang, Donghe; Miles, Andrew J; Eckford, Paul D W; Molinski, Steven; Wallace, B A; Bear, Christine E

Chin, Stephanie; Yang, Donghe; Miles, Andrew J; Eckford, Paul D W; Molinski, Steven; Wallace, B A; Bear, Christine E.

Afiliación

Chin S; From the Programme of Molecular Structure and Function, Hospital for Sick Children, Toronto M5G 0A4, Canada; the Department of Biochemistry, University of Toronto, Toronto, Canada.
Yang D; From the Programme of Molecular Structure and Function, Hospital for Sick Children, Toronto M5G 0A4, Canada.
Miles AJ; the Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom.
Eckford PDW; From the Programme of Molecular Structure and Function, Hospital for Sick Children, Toronto M5G 0A4, Canada.
Molinski S; From the Programme of Molecular Structure and Function, Hospital for Sick Children, Toronto M5G 0A4, Canada; the Department of Biochemistry, University of Toronto, Toronto, Canada.
Wallace BA; the Institute of Structural and Molecular Biology, Birkbeck College, University of London, London WC1E 7HX, United Kingdom.
Bear CE; From the Programme of Molecular Structure and Function, Hospital for Sick Children, Toronto M5G 0A4, Canada; the Department of Biochemistry, University of Toronto, Toronto, Canada; the Department of Physiology, University of Toronto, Toronto, Canada. Electronic address: bear@sickkids.ca.

J Biol Chem ; 292(5): 1988-1999, 2017 02 03.

Article en En | MEDLINE | ID: mdl-28003367

Asunto(s)

Regulador de Conductancia de Transmembrana de Fibrosis Quística/metabolismo; Fibrosis Quística/metabolismo; Mutación Missense; Sustitución de Aminoácidos; Proteínas Quinasas Dependientes de AMP Cíclico/genética; Proteínas Quinasas Dependientes de AMP Cíclico/metabolismo; Fibrosis Quística/genética; Regulador de Conductancia de Transmembrana de Fibrosis Quística/genética; Células HEK293; Humanos; Fosforilación/genética; Dominios Proteicos

Palabras clave

cysteine-mediated cross-linking; cystic fibrosis transmembrane conductance regulator (CFTR); ion channel; phosphorylation; spectroscopy; synchrotron radiation circular dichroism

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Regulador de Conductancia de Transmembrana de Fibrosis Quística / Mutación Missense / Fibrosis Quística Límite: Humans Idioma: En Revista: J Biol Chem Año: 2017 Tipo del documento: Article País de afiliación: Canadá

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