Effects of Deltorphin II and Its Retroenantio Analog on Cardiac Tolerance to Ischemia and Reperfusion.
Bull Exp Biol Med
; 162(3): 306-309, 2017 Jan.
Article
en En
| MEDLINE
| ID: mdl-28091919
ABSTRACT
Selective agonist of δ2-opioid receptors deltorphin II and its retroenantio analog (0.12 mg/kg intravenously) were preventively injected to male Wistar rats 15 min prior to 45-min coronary occlusion or 5 min before 120-min reperfusion. Administration of deltorphin II before artery occlusion and before reperfusion decreased the infarct size/area at risk ratio. Deltorphin II prevented the appearance of ischemia-provoked ventricular arrhythmias and exerted no effect on HR and BP (systolic and diastolic). The retroenantio analog of deltorphin II produced no antiarrhythmic or infarct-limiting effects, but reduced HR without affecting BP. Deltorphin II can be viewed as a promising prototype for a medicinal remedy to treat acute myocardial infarction.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Oligopéptidos
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Arritmias Cardíacas
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Cardiotónicos
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Daño por Reperfusión Miocárdica
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Analgésicos Opioides
Límite:
Animals
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2017
Tipo del documento:
Article
País de afiliación:
Rusia