Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes.

Liu, Y-P; Rajamanikham, V; Baron, M; Patel, S; Mathur, S K; Schwantes, E A; Ober, C; Jackson, D J; Gern, J E; Lemanske, R F; Smith, J A

Liu, Y-P; Rajamanikham, V; Baron, M; Patel, S; Mathur, S K; Schwantes, E A; Ober, C; Jackson, D J; Gern, J E; Lemanske, R F; Smith, J A.

Afiliación

Liu YP; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Rajamanikham V; Department of Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Baron M; Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
Patel S; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Mathur SK; Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Schwantes EA; Division of Allergy, Pulmonary and Critical Care, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Ober C; Department of Human Genetics, University of Chicago, Chicago, IL, USA.
Jackson DJ; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Gern JE; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Lemanske RF; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Smith JA; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Clin Exp Allergy ; 47(3): 371-382, 2017 Mar.

Article en En | MEDLINE | ID: mdl-28192616

Asunto(s)

Estrés del Retículo Endoplásmico/genética; Interferón Tipo I/metabolismo; Leucocitos/metabolismo; Proteínas de la Membrana/genética; Infecciones por Picornaviridae/genética; Infecciones por Picornaviridae/metabolismo; Rhinovirus/fisiología; Adulto; Asma/etiología; Asma/metabolismo; Linfocitos B/inmunología; Linfocitos B/metabolismo; Línea Celular; Cromosomas Humanos Par 17; Células Dendríticas/inmunología; Células Dendríticas/metabolismo; Chaperón BiP del Retículo Endoplásmico; Regulación de la Expresión Génica; Predisposición Genética a la Enfermedad; Genotipo; Proteínas de Choque Térmico/genética; Humanos; Interferón Tipo I/genética; Persona de Mediana Edad; Infecciones por Picornaviridae/virología

Palabras clave

17q21; IFN=beta unfolded protein response; ORMDL3; Rhinovirus; asthma; basic mechanisms

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Rhinovirus / Interferón Tipo I / Infecciones por Picornaviridae / Estrés del Retículo Endoplásmico / Leucocitos / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Adult / Humans / Middle aged Idioma: En Revista: Clin Exp Allergy Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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