Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen.
Bioorg Med Chem Lett
; 27(9): 1983-1988, 2017 05 01.
Article
en En
| MEDLINE
| ID: mdl-28351593
ABSTRACT
Cell surface carbohydrates of the Lewis blood group antigens, Lewis X (Lex), Lewis Y (Ley), Lewis A (Lea), and their sialylated derivatives, such as sialy Lewis X (sLex) and sialy Lewis A (sLea), play important roles in various recognition processes. These cell surface carbohydrates have also been associated with the development and progression of many types of cancers. Recently, we synthesized four anthracene-based fluorescent bisboronic acid sensors (compounds 2a-d) linked by 'click' chemistry with tethers of different lengths to match the epitope of various Lewis group of sugars. Among the four compounds, 2a appears to have both high sensitivity and selectivity for Ley among other carbohydrate antigens.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triazoles
/
Ácidos Borónicos
/
Colorantes Fluorescentes
/
Antígenos del Grupo Sanguíneo de Lewis
/
Antracenos
Límite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2017
Tipo del documento:
Article
País de afiliación:
China