Effect of Graphene on Nonneuronal and Neuronal Cell Viability and Stress.
Nano Lett
; 17(5): 3297-3301, 2017 05 10.
Article
en En
| MEDLINE
| ID: mdl-28383278
ABSTRACT
In recent years graphene has drawn considerable research interest for biomedical applications. However, applications of graphene in biological systems also raise concerns about its possible toxicity. Here, by using live cell imaging techniques, we investigate the effect of pristine graphene on the viability as well as stress of both nonneuronal and neuronal cells under physiological conditions. We find that graphene promotes cell adhesion and proliferation. Furthermore, we find that graphene has no detectable adverse effect on mitochondrial membrane potential and morphology, or autophagy levels in the cell, indicating that graphene does not induce cell stress. Our results highlight the potential of graphene to be used in biomedical applications by providing long-term and stable nonneural and neural interfaces.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Nanopartículas
/
Fibroblastos
/
Grafito
/
Neuronas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nano Lett
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos