Catalytic Enantioselective Synthesis of 2,5-Dihydrooxepines.
Angew Chem Int Ed Engl
; 56(30): 8663-8666, 2017 07 17.
Article
en En
| MEDLINE
| ID: mdl-28418120
ABSTRACT
A Michael addition initiated cyclopropanation/retro-Claisen rearrangement tandem reaction was developed for the enantioselective synthesis of highly functionalized 2,5-dihydrooxepines. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeds to give good yields and high enantioselectivity.
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MEDLINE
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En
Revista:
Angew Chem Int Ed Engl
Año:
2017
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Article