Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].

Xue, You-Lin; Wang, Hao; Riedy, Michael; Roberts, Brittany-Lee; Sun, Yuna; Song, Yong-Bo; Jones, Gary W; Masison, Daniel C; Song, Youtao

Molecular dynamics simulations of Hsp40 J-domain mutants identifies disruption of the critical HPD-motif as the key factor for impaired curing in vivo of the yeast prion [URE3].

Xue, You-Lin; Wang, Hao; Riedy, Michael; Roberts, Brittany-Lee; Sun, Yuna; Song, Yong-Bo; Jones, Gary W; Masison, Daniel C; Song, Youtao.

Afiliación

Xue YL; a School of Environmental Science, Liaoning University , Shenyang , China.
Wang H; d Light Industry College, Liaoning University , Shenyang , China.
Riedy M; a School of Environmental Science, Liaoning University , Shenyang , China.
Roberts BL; b Laboratory of Biochemistry and Genetics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , MD , USA.
Sun Y; b Laboratory of Biochemistry and Genetics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , MD , USA.
Song YB; a School of Environmental Science, Liaoning University , Shenyang , China.
Jones GW; e School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University , Shenyang , China.
Masison DC; c National University of Ireland Maynooth , Maynooth , Ireland.
Song Y; b Laboratory of Biochemistry and Genetics , National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health , Bethesda , MD , USA.

J Biomol Struct Dyn ; 36(7): 1764-1775, 2018 May.

Article en En | MEDLINE | ID: mdl-28766406

Asunto(s)

Proteínas HSP70 de Choque Térmico/genética; Mutación/genética; Priones/genética; Estructura Terciaria de Proteína/genética; Proteínas de Saccharomyces cerevisiae/genética; Saccharomyces cerevisiae/genética; Simulación de Dinámica Molecular

Palabras clave

Hsp40−Hsp70 interaction; MD simulation; conformational change; heat shock protein; molecular docking

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Saccharomyces cerevisiae / Priones / Estructura Terciaria de Proteína / Proteínas HSP70 de Choque Térmico / Proteínas de Saccharomyces cerevisiae / Mutación Tipo de estudio: Prognostic_studies Idioma: En Revista: J Biomol Struct Dyn Año: 2018 Tipo del documento: Article País de afiliación: China

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