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Gold(I)-Initiated Cycloisomerization/Diels-Alder/Retro-Diels-Alder Cascade Strategy to Biaryls.
Jin, Shengfei; Niu, Yujie; Liu, Chengjun; Zhu, Lifeng; Li, Yangming; Cui, Shanshan; Xiong, Zhiling; Cheng, Maosheng; Lin, Bin; Liu, Yongxiang.
Afiliación
  • Jin S; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Niu Y; Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
  • Liu C; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Zhu L; Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Li Y; Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
  • Cui S; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Xiong Z; Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Cheng M; Institute of Drug Research in Medicine Capital of China , Benxi 117000, P. R. China.
  • Lin B; Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
  • Liu Y; Wuya College of Innovation, Shenyang Pharmaceutical University , Shenyang 110016, P. R. China.
J Org Chem ; 82(17): 9066-9074, 2017 09 01.
Article en En | MEDLINE | ID: mdl-28776369
ABSTRACT
A unique approach to biaryls was developed on the basis of propargyl vinyl ethers and dienophiles substrates via a gold(I)-initiated cycloisomerization/Diels-Alder/retro-Diels-Alder cascade reaction. The scope and mechanism of the reaction were investigated on the basis of a series of synthetic substrates, control experiments, and DFT calculations.
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2017 Tipo del documento: Article