Direct and Stereospecific [3+2] Synthesis of Pyrrolidines from Simple Unactivated Alkenes.
Angew Chem Int Ed Engl
; 56(42): 12962-12966, 2017 10 09.
Article
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| MEDLINE
| ID: mdl-28816407
ABSTRACT
Pyrrolidines are important heterocyclic compounds with endless applications in organic synthesis, metal catalysis, and organocatalysis. Their potential as ligands for first-row transition-metal catalysts inspired a new method to access complex poly-heterocyclic pyrrolidines in one step from available materials. This fundamental step forward is based on the discovery of an essential organoaluminum promoter that engages unactivated and electron-rich olefins in intermolecular [3+2] cycloadditions.
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Angew Chem Int Ed Engl
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2017
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Article
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Suecia