Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover.

Mascarenhas, Romila; Le, Hoang V; Clevenger, Kenneth D; Lehrer, Helaina J; Ringe, Dagmar; Kelleher, Neil L; Silverman, Richard B; Liu, Dali

Mascarenhas, Romila; Le, Hoang V; Clevenger, Kenneth D; Lehrer, Helaina J; Ringe, Dagmar; Kelleher, Neil L; Silverman, Richard B; Liu, Dali.

Afiliación

Mascarenhas R; Department of Chemistry and Biochemistry, Loyola University Chicago , Chicago, Illinois 60660, United States.
Le HV; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208, United States.
Clevenger KD; Department of BioMolecular Sciences and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi , University, Mississippi 38677, United States.
Lehrer HJ; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208, United States.
Ringe D; Departments of Chemistry and Biochemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University , Waltham, Massachusetts 02454-9110, United States.
Kelleher NL; Departments of Chemistry and Biochemistry and Rosenstiel Basic Medical Sciences Research Center, Brandeis University , Waltham, Massachusetts 02454-9110, United States.
Silverman RB; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208, United States.
Liu D; Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, and Center for Molecular Innovation and Drug Discovery, Northwestern University , Evanston, Illinois 60208, United States.

Biochemistry ; 56(37): 4951-4961, 2017 09 19.

Article en En | MEDLINE | ID: mdl-28816437

Asunto(s)

4-Aminobutirato Transaminasa/antagonistas & inhibidores; Aspartato Aminotransferasas/antagonistas & inhibidores; Cicloleucina/análogos & derivados; Inhibidores Enzimáticos/farmacología; Modelos Moleculares; Ornitina-Oxo-Ácido Transaminasa/antagonistas & inhibidores; Fosfato de Piridoxal/metabolismo; 4-Aminobutirato Transaminasa/química; 4-Aminobutirato Transaminasa/metabolismo; Aspartato Aminotransferasas/química; Aspartato Aminotransferasas/genética; Aspartato Aminotransferasas/metabolismo; Sitios de Unión; Dominio Catalítico; Cristalografía por Rayos X; Cicloleucina/química; Cicloleucina/metabolismo; Cicloleucina/farmacología; Bases de Datos de Compuestos Químicos; Bases de Datos de Proteínas; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/metabolismo; Proteínas de Escherichia coli/antagonistas & inhibidores; Proteínas de Escherichia coli/química; Proteínas de Escherichia coli/genética; Proteínas de Escherichia coli/metabolismo; Humanos; Ligandos; Conformación Molecular; Ornitina-Oxo-Ácido Transaminasa/química; Ornitina-Oxo-Ácido Transaminasa/genética; Ornitina-Oxo-Ácido Transaminasa/metabolismo; Conformación Proteica; Fosfato de Piridoxal/química; Piridoxamina/química; Piridoxamina/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Homología Estructural de Proteína; Especificidad por Sustrato

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ornitina-Oxo-Ácido Transaminasa / Fosfato de Piridoxal / Aspartato Aminotransferasas / Modelos Moleculares / Cicloleucina / Inhibidores Enzimáticos / 4-Aminobutirato Transaminasa Idioma: En Revista: Biochemistry Año: 2017 Tipo del documento: Article País de afiliación: Estados Unidos

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