The quantitative link of lung clearance index to bronchial segments affected by bronchiectasis.
Thorax
; 73(1): 82-84, 2018 01.
Article
en En
| MEDLINE
| ID: mdl-28866642
ABSTRACT
In adult patients with cystic fibrosis (CF), the lung clearance index (LCI) derived from the multiple breath washout relates to both acinar and conductive ventilation heterogeneity. The latter component predicts an association between LCI and the number of bronchial segments affected by bronchiectasis. Here, we experimentally demonstrated this association in patients with CF, and also examined an ancillary group of patients with non-CF bronchiectasis. We conclude that lung disease severity in terms of number of bronchial segments results in an associated LCI increase, likely constituting a portion of LCI that cannot be reversed by treatment in patients with CF lung disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Bronquiectasia
/
Fibrosis Quística
Tipo de estudio:
Etiology_studies
/
Observational_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Thorax
Año:
2018
Tipo del documento:
Article
País de afiliación:
Bélgica