Bioengineering of Artificial Antigen Presenting Cells and Lymphoid Organs.
Theranostics
; 7(14): 3504-3516, 2017.
Article
en En
| MEDLINE
| ID: mdl-28912891
ABSTRACT
The immune system protects the body against a wide range of infectious diseases and cancer by leveraging the efficiency of immune cells and lymphoid organs. Over the past decade, immune cell/organ therapies based on the manipulation, infusion, and implantation of autologous or allogeneic immune cells/organs into patients have been widely tested and have made great progress in clinical applications. Despite these advances, therapy with natural immune cells or lymphoid organs is relatively expensive and time-consuming. Alternatively, biomimetic materials and strategies have been applied to develop artificial immune cells and lymphoid organs, which have attracted considerable attentions. In this review, we survey the latest studies on engineering biomimetic materials for immunotherapy, focusing on the perspectives of bioengineering artificial antigen presenting cells and lymphoid organs. The opportunities and challenges of this field are also discussed.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Células Artificiales
/
Tejido Linfoide
/
Células Presentadoras de Antígenos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Theranostics
Año:
2017
Tipo del documento:
Article
País de afiliación:
Estados Unidos