Expression of proto-oncogenes in normal and tumor tissues of human skin.
J Invest Dermatol
; 90(6): 841-4, 1988 Jun.
Article
en En
| MEDLINE
| ID: mdl-2897396
ABSTRACT
The expression of c-fos, c-myc, Ha-ras, N-ras, EGF-receptor, and cardiac actin genes was examined in 7 normal epidermis, 3 cellular nevi, and 8 skin tumors including 6 malignant and 2 benign tumors of human origin. These genes were transcribed in most normal and tumor tissues, though no tumor-specific expression of proto-oncogenes (c-fos, c-myc, Ha-ras, and N-ras) could be detected. However, there was a characteristic parallelism between the expression of c-fos and c-myc in normal epidermis, while the parallelism was not always definite in skin tumors. The ratio of c-fos/c-myc transcripts in normal epidermis was constant compared with the expression of other genes examined. These data suggest that c-fos and c-myc are expressed in all normal skin tissues, and that maintenance of a constant ratio of c-fos/c-myc is closely related to ordered cell growth of the tissues.
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Banco de datos:
MEDLINE
Asunto principal:
Neoplasias Cutáneas
/
Proto-Oncogenes
/
Proteínas Proto-Oncogénicas
/
Epidermis
/
Proteínas de Neoplasias
Límite:
Humans
Idioma:
En
Revista:
J Invest Dermatol
Año:
1988
Tipo del documento:
Article
País de afiliación:
Japón