Hepatoprotective effect of peony total glucosides and the underlying mechanisms in diabetic rats.
Pharm Biol
; 55(1): 2178-2187, 2017 Dec.
Article
en En
| MEDLINE
| ID: mdl-29078720
ABSTRACT
CONTEXT Total glucosides of peony (TGP), compounds extracted from the dried roots of Paeonia lactiflora Pall, have been reported to have anti-inflammatory and antioxidative activities. However, the protective effect of TGP on liver injury and the underlying mechanisms remains unknown in diabetic rats. OBJECTIVES:
Current study investigates prevention of liver injury by TGP in diabetic rats and its mechanism was related to the inhibition of endoplasmic reticulum stress (ERS). MATERIALS ANDMETHODS:
Fifty adult male rats were randomly divided into Normal group, diabetic group, TGP (50, 100 and 200 mg/kg/day) treatment groups (n = 10 per group). At the end of the 8th week, the liver was removed for biochemical and histological examinations.RESULTS:
Compared with the diabetic group, administration of TGP at doses of 50, 100 and 200 mg/kg significantly prevented the increase of hepatic fibrosis score (ED50 139.4 mg/kg). Compared with diabetic group, TGP at doses of 50, 100 and 200 mg/kg showed an inhibition on the increased macrophage infiltration. MCP-1 and TNF-α mRNA and protein expression were significantly increased in diabetic group compared with normal group; TGP administration caused significant reduction of high levels of MCP-1 and TNF-α mRNA as well as protein levels. Also, TGP at all doses showed an inhibition on the increased GRP78 levels, p-Perk levels and p-Eif2α levels in liver from diabetic group. DISCUSSION ANDCONCLUSIONS:
Our results indicate that TGP has potential as a treatment for diabetic liver injury attenuating liver lipid accumulation and inflammation as well as ERS induced by diabetic condition.Palabras clave
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Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
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Paeonia
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Diabetes Mellitus Experimental
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Glucósidos
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Hígado
Límite:
Animals
Idioma:
En
Revista:
Pharm Biol
Año:
2017
Tipo del documento:
Article