BRCA1 deficiency is a recurrent event in early-onset triple-negative breast cancer: a comprehensive analysis of germline mutations and somatic promoter methylation.

Brianese, Rafael Canfield; Nakamura, Kivvi Duarte de Mello; Almeida, Fernanda Gabriella Dos Santos Ramos de; Ramalho, Rodrigo Fernandes; Barros, Bruna Durães de Figueiredo; Ferreira, Elisa Napolitano E; Formiga, Maria Nirvana da Cruz; de Andrade, Victor Piana; de Lima, Vladmir Claudio Cordeiro; Carraro, Dirce Maria

Brianese, Rafael Canfield; Nakamura, Kivvi Duarte de Mello; Almeida, Fernanda Gabriella Dos Santos Ramos de; Ramalho, Rodrigo Fernandes; Barros, Bruna Durães de Figueiredo; Ferreira, Elisa Napolitano E; Formiga, Maria Nirvana da Cruz; de Andrade, Victor Piana; de Lima, Vladmir Claudio Cordeiro; Carraro, Dirce Maria.

Afiliación

Brianese RC; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Nakamura KDM; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Almeida FGDSR; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Ramalho RF; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Barros BDF; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Ferreira ENE; Laboratory of Genomics and Molecular Biology, CIPE - A. C. Camargo Cancer Center, São Paulo, Brazil.
Formiga MNDC; Department of Oncogenetics, A. C. Camargo Cancer Center, São Paulo, Brazil.
de Andrade VP; Department of Medical Oncology, A. C. Camargo Cancer Center, São Paulo, Brazil.
de Lima VCC; Department of Anatomic Pathology, A. C. Camargo Cancer Center, São Paulo, Brazil.
Carraro DM; Department of Medical Oncology, A. C. Camargo Cancer Center, São Paulo, Brazil.

Breast Cancer Res Treat ; 167(3): 803-814, 2018 02.

Article en En | MEDLINE | ID: mdl-29116469

Asunto(s)

Proteína BRCA1/genética; Metilación de ADN/genética; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Neoplasias de la Mama Triple Negativas/genética; Adolescente; Adulto; Edad de Inicio; Anciano; Anciano de 80 o más Años; Proteína BRCA2/genética; Supervivencia sin Enfermedad; Femenino; Mutación de Línea Germinal/genética; Heterocigoto; Humanos; Persona de Mediana Edad; Inhibidores de Poli(ADP-Ribosa) Polimerasas/uso terapéutico; Regiones Promotoras Genéticas; Neoplasias de la Mama Triple Negativas/epidemiología; Neoplasias de la Mama Triple Negativas/patología; Adulto Joven

Palabras clave

BRCA1; Germline; Methylation; Mutation; Somatic; Triple-negative breast cancer

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteína BRCA1 / Metilación de ADN / Neoplasias de la Mama Triple Negativas Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Breast Cancer Res Treat Año: 2018 Tipo del documento: Article País de afiliación: Brasil

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google