Liver injury induced by clomiphene citrate: A case report and literature reviews.
J Clin Pharm Ther
; 43(2): 299-301, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29150839
ABSTRACT
WHAT IS KNOWN AND OBJECTIVE:
Clomiphene citrate is used to cause ovulation in females and to increase semen production in males. Clomiphene citrate is well tolerated in most patients and rarely induces liver injury. We report a case of liver injury which is associated with administration of clomiphene citrate in a male patient. CASESUMMARY:
A 31-year-old man who was treated by clomiphene citrate for 5 days was transferred to our emergency room with reddish-brown urine and upper abdominal pain. The levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were elevated. Based on the subsequent examination, he was diagnosed with liver injury and cholecystitis. The levels of AST and ALT returned to normal range after discontinuation of clomiphene citrate and symptomatic treatment. WHAT IS NEW ANDCONCLUSION:
The mechanism of liver injury caused by clomiphene citrate is still unclear. Polymorphism of CYP2D6 may have had an effect. Liver function tests should be performed when there is upper abdominal pain after administration of clomiphene citrate.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Clomifeno
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Hígado
Límite:
Adult
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Clin Pharm Ther
Asunto de la revista:
FARMACIA
/
TERAPEUTICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
China