C<sub>60</sub> fullerenes disrupt cellular signalling leading to TRPC4 and TRPC6 channels opening by the activation of muscarinic receptors and G-proteins in small intestinal smooth muscles.

Dryn, Dariia O; Melnyk, Mariia I; Al Kury, Lina T; Prylutskyy, Yuriy I; Ritter, Uwe; Zholos, Alexander V

C₆₀ fullerenes disrupt cellular signalling leading to TRPC4 and TRPC6 channels opening by the activation of muscarinic receptors and G-proteins in small intestinal smooth muscles.

Dryn, Dariia O; Melnyk, Mariia I; Al Kury, Lina T; Prylutskyy, Yuriy I; Ritter, Uwe; Zholos, Alexander V.

Afiliación

Dryn DO; A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4 Bogomoletz Street, 01024 Kyiv, Ukraine; Institute of Pharmacology and Toxicology, National Academy of Medical Science, 14 Eugene Pottier Street, 03057 Kyiv, Ukraine.
Melnyk MI; A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4 Bogomoletz Street, 01024 Kyiv, Ukraine; Institute of Pharmacology and Toxicology, National Academy of Medical Science, 14 Eugene Pottier Street, 03057 Kyiv, Ukraine.
Al Kury LT; Zayed University, P.O. Box 144534, Abu Dhabi, United Arab Emirates.
Prylutskyy YI; Taras Shevchenko National University of Kyiv, ESC "Institute of Biology and Medicine", 64 Volodymyrska Street, 01601 Kyiv, Ukraine.
Ritter U; Technical University of Ilmenau, Institute of Chemistry and Biotechnology, 25 Weimarer Street, 98693 Ilmenau, Germany.
Zholos AV; A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 4 Bogomoletz Street, 01024 Kyiv, Ukraine; Taras Shevchenko National University of Kyiv, ESC "Institute of Biology and Medicine", 64 Volodymyrska Street, 01601 Kyiv, Ukraine. Electronic address: a.zholos@univ.net.ua.

Cell Signal ; 43: 40-46, 2018 03.

Article en En | MEDLINE | ID: mdl-29242169

Asunto(s)

Fulerenos/toxicidad; Proteínas de Unión al GTP/metabolismo; Intestino Delgado/citología; Miocitos del Músculo Liso/metabolismo; Receptores Muscarínicos/metabolismo; Transducción de Señal/efectos de los fármacos; Canales Catiónicos TRPC/metabolismo; Canal Catiónico TRPC6/metabolismo; Animales; Activación del Canal Iónico/efectos de los fármacos; Masculino; Ratones Endogámicos BALB C; Miocitos del Músculo Liso/efectos de los fármacos; Nanopartículas/toxicidad

Palabras clave

C(60) fullerene nanoparticles; Ca(2+) signalling; Smooth muscle cells; TRPC4 cation channels; Transient receptor potential channels

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / Receptores Muscarínicos / Proteínas de Unión al GTP / Miocitos del Músculo Liso / Fulerenos / Canales Catiónicos TRPC / Canal Catiónico TRPC6 / Intestino Delgado Límite: Animals Idioma: En Revista: Cell Signal Año: 2018 Tipo del documento: Article País de afiliación: Ucrania

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