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Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl.
Yoshida, Hiroshi; Yamada, Hajime; Nogami, Wataru; Dohi, Keiji; Kurino-Yamada, Tomomi; Sugiyama, Koji; Takahashi, Koji; Gahara, Yoshinari; Kitaura, Motoji; Hasegawa, Minoru; Oshima, Itsuki; Kuwabara, Kenji.
Afiliación
  • Yoshida H; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Yamada H; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Nogami W; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Dohi K; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Kurino-Yamada T; Biomarker R & D Department, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Sugiyama K; Human Resources & Administration Department, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Takahashi K; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Gahara Y; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Kitaura M; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Hasegawa M; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Oshima I; Pharmaceutical Research Division, Human Resources & Administration Department, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan.
  • Kuwabara K; Drug Discovery & Disease Research Laboratory, Shionogi & Co., Ltd., Toyonaka City, Osaka, Japan. Electronic address: kenji.kuwabara@shionogi.co.jp.
Exp Hematol ; 59: 30-39.e2, 2018 03.
Article en En | MEDLINE | ID: mdl-29274361
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiazoles / Megacariocitos / Cinamatos / Proliferación Celular / Receptores de Trombopoyetina / Modelos Biológicos Límite: Animals / Humans Idioma: En Revista: Exp Hematol Año: 2018 Tipo del documento: Article País de afiliación: Japón
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tiazoles / Megacariocitos / Cinamatos / Proliferación Celular / Receptores de Trombopoyetina / Modelos Biológicos Límite: Animals / Humans Idioma: En Revista: Exp Hematol Año: 2018 Tipo del documento: Article País de afiliación: Japón